Not all prostaglandins are inflammatory and vaso-constrictive, but when you block their formation, you block those that are anti-inflammatory and vaso-dialating as well as the inflammatory and constrictive hormones. Prostaglandins made from omega-6 are inflammatory and vaso-constrictive. It is better to reduce the inflammation by reducing your omega-6 and increasing your omega-3. When I did that by following the Oil Change Diet, I was able stop taking NSAIDS and blood pressure medication in just 3 weeks.
Public Release: 12-Nov-2015
Vanderbilt University Medical Center study sheds light on side effects of COX-2 drugs
Vanderbilt University Medical Center
It’s been about a decade since the promise of COX-2 inhibitors — drugs that relieve arthritis pain and inflammation without the gastrointestinal side effects of other painkillers — was tempered by the realization that they could cause heart problems in some patients.
Now a team of Vanderbilt University Medical Center scientists led by Ming-Zhi Zhang M.D., M.Sc., and Raymond C. Harris, M.D., are closer to understanding why. They have found that production of prostaglandins by macrophages may play a role, especially in the kidney and the skin.
Their findings, published in the Journal of Clinical Investigation, could lead to development of a new, better-targeted class of drugs that relieve pain without causing vascular effects.
Prostaglandins are molecules produced by the cyclooxygenase enzymes — COX-1 and COX-2 — that play…
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